Prof.ssa Alessandra Braca
PhD project Title:
Bioprospecting of Mediterranean flora: researching natural products with medicinal and nutritional value
The subject of this research project is the phytochemical and biological study of endemic plants belonging to different families to exploit the biodiversity of Mediterranean flora following by a bioprospecting approach. Bioprospecting is “the search for plant and animal species from which medicinal drugs and other commercially valuable compounds can be obtained”. According to this idea, the study of endemic plants in the continuous search for new herbal drugs, herbal preparations and food within the Mediterranean biodiversity is of pivotal importance to enhance and preserve this unique genetic resource, exploit its potential economic value and improve human well-being. The experimental steps of the project include the selection of plants of Mediterranean area, belonging to different genus for their chemotaxonomic, phylogenetic, traditional, and medicinal features; the extraction of plant material with solvents of different polarity; the isolation of active constituents by chromatographic processes such as HPLC, CPC, GC, flash chromatography, gel filtration chromatography; the chemical characterization of the isolated compounds using NMR, MS and UV techniques; and the evaluation of their biological activity, as leads for the design of new drugs.
Oral communications at congress:
Anna Maria Iannuzzi>, Alessandra Braca, Chiara Sinisgalli, Marinella De Leo, Luigi Milella, Angela Ostuni, Sergio Giani, Rokia Sanogo. Adansonia digitata L. (Baobab) from Mali: Phytochemical profile, antioxidant and antidiabetic activities of its fruit pulp and leaves. XVI Congress of the Italian society of Phytochemistry jointly 2nd International Congress on Edible, Medicinal and Aromatic Plants (ICEMAP 2019). Alghero, June 19-21, 2019.
Poster communications at congress:
Anna Maria Iannuzzi, César Munoz Camero, Khadidja Aya Beladjila, Marinella De Leo, Valeria D’Angelo, Maria Pala Germanò, Smain Amira, Ammar Bader, Nunziatina De Tommasi, Alessandra Braca. Antiangiogenic activity of iridoids from Lamiaceae and Plantaginaceae species. 67th International Congress and Annual meeting of the Society for Medicina plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognsy AFERP. Innsbruck, Austria, September 1-4, 2019, p. 311, PO-368.
Anna Maria Iannuzzi, Fabiano Camangi, Marinella De Leo, Alessandra Braca, Nunziatina De Tommasi. Phytochemical profile of Cornus sanguinea L. fruit. 114° congresso della Società Botanica Italiana.VI international plant science conference (IPSC). Padova, September 4-6, 2019, p. 114, PO-168.
M. Iannuzzi, M. De Leo, A. Braca. Chemical profile of wild and cultivated Salsola soda aerial parts. The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research jointly with the 11th Shanghai International Conference on Traditional Chinese Medicine and Natural Medicine, Shanghai, China, 26-29 August 2018, p. 88-89, PO-72.
Guillen Huallpa, A. M. Iannuzzi, M. De Leo, N. De Tommasi, C. Granchi, A. Braca. Clerodanes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL). The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research jointly with the 11th Shanghai International Conference on Traditional Chinese Medicine and Natural Medicine, Shanghai, China, 26-29 August 2018, p. 100-101, PO-88.
De Leo, F. Camangi, B. Muscatello, A. M. Iannuzzi, C. Giacomelli, F. Graziani, M. L. Trincavelli, C. Martini, A. Braca. Phytochemical analysis and antisenescence activity of Sorbus torminalis (L.) Crantz and Elaeagnus umbellata Thunb fruits. 113° Congresso della Società Botanica Italiana V International Plant Science Conference, Fisciano (SA), 12-15 September 2018, CO17, p.51.