Contacts:
Tel: 050 2219703
e-mail: giulia.bononi@phd.unipi.it
Supervisors:
Prof. Filippo Minutolo, Prof. Carlotta Granchi
PhD project Title:
Development of therapeutic and diagnostic agents targeting tumor lipid and sugar metabolism
Research summary:
I am a PhD student in Medicinal Chemistry and my research project is focused on the development of therapeutic and diagnostic agents targeting tumor lipid and sugar metabolism. In particular, I am currently working on two projects: the first one concerns the design, synthesis and biological evaluation of new reversible inhibitors of monoacyglycerol lipase (MGL); the second one is focused on the design, synthesis and optimization of molecular probes which may be used for the imaging of glycolytic cancer cells.
Publications:
Oral communications at congress:
TUMA 2018 XXXVI Convegno interregionale (Pisa, October 4-5, 2018). Oral communication: Bononi G., Granchi C., Rizzolio F., Chicca A., Katzenellenbogen J. A., Tuccinardi T., Minutolo F. “Discovery and optimization of salicylketoxime derivatives as potent and reversible MAGL inhibitors”.
Poster communications at congress:
CFF 2019 – Chemistry for the Future International Conference, (Pisa, July 3-5, 2019). Poster communication: G. Bononi, F. Rizzolio, A. Chicca, J. Katzenellenbogen, M. Macchia, T. Tuccinardi, C. Granchi, F. Minutolo. “Design and optimization of salicylketoximes as reversible and selective MAGL inhibitors”.
NMMC 2019 – XXVI National Meeting in Medicinal Chemistry and XII Young Medicinal Chemists’ Symposium (Nuove Prospettive in Chimica Farmaceutica – NPCF12), (Milan, July 16-19, 2019). Poster communication: G. Bononi, F. Rizzolio, A. Chicca, J. Katzenellenbogen, M. Macchia, T. Tuccinardi, C. Granchi, F. Minutolo; “Synthesis of ketoximic derivatives and their optimization as potent reversible MAGL inhibitors”.